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Student researchers honored with nationally competitive awards

The University of Tulsa’s 2020 nationally competitive award winners include a Goldwater Scholar, a recipient of the National Science Foundation Graduate Research Fellowship, two Fulbright Canada-MITACS Globalink Research Internship recipients and three Gilman Scholars. 

Goldwater Scholar 

nationally competitive awardsMechanical engineering junior Emily Tran of Broken Arrow is one of 396 students from across the United States to win a Barry Goldwater Scholarship. Students majoring in mathematics, the natural sciences and engineering were nominated to apply for the award, which recognizes scientific talent. 

In the summer of 2019, Tran worked as a Vanderbilt Institute of Surgical Engineering (VISE) Fellow in the Medical Engineering and Discovery (MED) and Computer Assisted Otologic Surgery (CAOS) labs alongside mechanical engineering alumna Katy Riojas (BS ’16)Tran participated in the design and development of a manual insertion tool for image-guided, minimally invasive cochlear implant surgery. Her summer involved analyzing CT scans, assisting in cadaver trials and designing a phantom model for user and force testing. 

Tran said she enjoys this type of research because it is at the cross section of engineering and medicine: “With this type of research, it is easy to see how heavily intertwined they can actually be. After pouring so much work into the research projects, there’s a certain indescribable feeling that comes with seeing the lives of the kids or patients benefit from it.” 

Tran also has assisted with Make a Difference Engineering (MADE at TU) projects and served as a student researcher in TU’s Tulsa Undergraduate Research Challenge (TURC). She has been a member of the TU Robotic Mining Crew, the Tau Beta Pi Engineering Honor Society and many other organizations and activities. 

Working at Vanderbilt opened Tran’s eyes to the direct interaction that often occurs between engineers and physicians seeking to develop life-changing technology. After graduating from TU, she plans to attend medical school and work as a clinical physician. “This experience made me aware of my love for research,” Tran explained. “I will continue working in medical and surgical device research in the future.”  

National Science Foundation Graduate Research Fellowship 

nationally competitive awardsStephanie Call (BS ’18) of Tulsa is a pre-med chemical engineering alumna currently pursuing a doctorate in chemical engineering at the University of Massachusetts Amherst. At TU, she participated on the women’s rowing team and expanded her scientific knowledge and critical thinking skills in her senior lab and design classes. 

At UMass AmherstCall will use her NSF Graduate Research Fellowship to focus on synthetic biology and genome engineering in bacteria. She uses CRISPR interference (CRISPRi) to engineer E. coli and S. aureus to elucidate the genes associated with cell attachment and biofilm formation on biomaterial surfaces, such as catheters and pacemakers. “By finding these genes and investigating their interactions, we hope to find potential targets that could be used to prevent and treat biofilm infections using targeted antimicrobials and/or antibiofouling agents,” Call said. 

After her PhDCall plans to become a professor and establish her own engineering lab to continue researching and developing new technologies. She also wants to teach and mentor the next generation of engineers and researchers. 

Fulbright Canada-MITACS Globalink Research Internship 

Biochemistry, pre-med student Ritvik Ganguly and John Reaves, a triple major in political science, Spanish and economics, were honored as inaugural Fulbright Canada-MITACS Globalink Research program interns. This internship program is offered to U.S. students interested in visiting Canada to undertake advanced research projects in their area of interest. Weeks after the announcement, however, the program was canceled due to the COVID-19 pandemic. 

nationally competitive awardsGanguly, of Tulsa, was scheduled to complete 12 weeks of research with a neurosurgeon in a neural repair and regeneration laboratory located in Toronto, OntarioHis project would have focused on human induced pluripotent stem cells that target the microenvironment of spinal cord injuries for the development of a new treatment for traumatic spinal cord injuries. 

Ganguly is a Presidential Scholar, Honors Scholar and a member of the TU College Philanthropy Initiative. He plans to attend medical school and pursue a career in internal medicine. 

“I believe that the future of medicine relies not only on our ability to innovate in the field of biomedical research, but also on our ability to foster cross-cultural academic exchanges and work together on a global scale,” he remarked. 

nationally competitive awardsReaves, from Fairview, Texas, would have spent his 12 weeks in Winnipeg, Manitoba, helping compile a history of the oil industries in the United States, Canada and Brazil, and using the data to perform economic forecasting. 

“I wanted something that would prepare me for whatever line of work I ended up in,” Reaves said. “My eventual career goal is to work for the U.S. State Department.”  

Both Ganguly and Reaves are members of the TU Honors Program, Global Scholars and many other extracurricular activities. 

Gilman International Scholarship 

Meagan Henningsen (sociology) of Tulsa; Manal Abu-Sheikh (psychology) of Broken Arrow, Oklahoma; and Paris Clark (international business, Spanish) of Silver Spring, Maryland, were selected to receive the Benjamin A. Gilman International Scholarship. The program is funded by the U.S. Department of State and supports study abroad opportunities for Pell Grant recipients. Unfortunately, the international adventures for Henningsen, Abu-Sheikh and Clark ended early due to the COVID-19 pandemic. Learn more about their global scholarships.

TU, LIBR partnership at the forefront of mental health research 

The Laureate Institute for Brain Research opened its doors 10 years ago to address one of Oklahoma’s worst health factors, mental health. As scientists and researchers discover the ways in which a person’s mental health is directly linked to their overall physical condition, LIBR, in collaboration with The University of Tulsa, is using new neuroscience tools and resources to answer old questions about Oklahoma’s health crisis.

LIBR
Director Martin Paulus

LIBR was founded by the William K. Warren Foundation when then scientific director Wayne Drevets and five other colleagues from the National Institutes of Health in Washington, D.C., transferred to Tulsa in 2009. Today, the organization includes seven principal investigators (PI) who have tenure track or tenure appointments in the OU-TU School of Community Medicine. The goal then and now is to conduct neuroscience-based research that will improve the diagnosis or prognosis of individuals with mental illness. LIBR Director Martin Paulus said the institute strives to respect the dignity of each patient while leveraging leading talent and technology to discover the causes of and cures for disorders related to mood, anxiety, eating and memory. “We’re trying to use neuroscience to find better ways to develop mental health interventions,” he said.

T-1000

When Paulus joined the LIBR staff in 2014, he set a goal to create a large data set that would allow researchers to investigate mental health prognosis and diagnosis through behavioral processes, neuroimaging, neuromodulation, psychophysiology and bioassays. LIBR’s largest research project, the Tulsa 1000 (T-1000) study, began recruiting participants with mood, anxiety, eating and substance disorders to complete more than 24 hours of baseline testing. The 1,000th and final individual was enrolled in 2018 with the goal of determining whether neuroscience-based measures can be used to predict outcomes in patients with mental illness.
Data Analytics Lead Rayus Kuplicki (B.S. ’09, M.S. ’11, Ph.D. ’14) has been heavily involved in the technical setup and analysis of T-1000 since its inception. He said the standardization of this initial data collection at the institute is critical for quality research. “My work has made it possible to take raw data from thousands of participants and compute the quantifiable traits that we compare across groups,” he explained.

LIBR
TU graduate student Bart Ford

Data analysis of T-1000 participants continues and has generated more than 40 scientific papers, currently in progress. TU graduate students in the areas of psychology, engineering and biology contribute to T-1000 research through subsets of data analysis. Biology doctoral student Bart Ford is collaborating with LIBR PI Jonathan Savitz to examine the link between latent viruses and depression. “It is well established that early life stress and childhood trauma increase the risk of physical and mental health problems later in life, but the biological mechanisms by which this occurs are not well understood,” Ford said. “Dr. Savitz and I wondered if people who experience childhood abuse and neglect are perhaps more vulnerable to a common latent herpes virus called cytomegalovirus (CMV).”

The virus is usually harmless in otherwise healthy individuals but can weaken the immune system over time. Savitz and Ford studied a group of individuals with major depressive disorder and found that higher levels of self-reported childhood abuse and neglect were associated with a greater likelihood of testing positive for CMV. They then used the T-1000 cohort to replicate the study and discovered the same results with similar effects in size. The findings were published in the prestigious “JAMA Psychiatry” journal earlier this year.
“We interpret this to mean that the stress of abuse and neglect during development may render a person susceptible to a CMV infection,” Ford stated. “This could suggest CMV contributes to later life health problems that are often seen in survivors of abuse.”

According to Savitz and Ford, T-1000 is beneficial in understanding the biological causes, mechanisms and outcomes of mental health disorders, and consequently, can help identify therapeutic targets that will lead to treatments of the sources and after-effects of mental illness.

ABCD

In addition to T-1000, another primary project ongoing at LIBR is the Adolescent Brain Cognitive Development (ABCD) initiative, a study of more than 11,878 children, ages 9 and 10, at 21 different sites nationwide. LIBR researchers have conducted detailed assessments of 743 of the participants. Follow-up visits and scans will continue for 10 years to examine the course of wellness and mental illness during the second decade of life when mental health disorders tend to emerge. One of the first papers the data generated in 2018 was accepted to the journal “NeuroImage” and entitled “Screen media activity and brain structure in youth: Evidence for diverse structural correlation networks from the ABCD study.”

TU Tough

LIBR
Professor Robin Aupperle

Robin Aupperle is another LIBR PI and assistant professor of community medicine who uses neuroscience and psychological research to improve mental health and gain insight into the causes of anxiety, depression and trauma. She is interested in identifying factors that support resilience to college-related stress and strategies to optimize a student’s psychological well-being. Paulus said meta-analyses show one in three students will develop significant anxiety and depression during their first year of college — a major reason why some students choose to drop out of school. That’s why Aupperle developed the four-week TU Tough program that teaches the skills and mindset necessary for mental toughness to effectively respond to stressful or challenging situations. “This is the idea that our abilities are not set in stone — that we can learn, improve and adapt,” she explained. “Likewise, our ability to be resilient in the face of stress is not hard-wired but can be built and strengthened through practicing certain skills as we seek out and face challenges.”

Aupperle is a mentor to graduate students such as TU clinical psychology Ph.D. student Tim McDermott. His predoctoral training grant application to the National Institute of Mental Health received a qualifying score for funding, which will support McDermott’s research to study the brain circuits underlying people’s ability to manage their emotional reactions. Understanding the brain circuits involved in the processing and regulating of emotions could potentially inform future anxiety and depression treatments. “We will examine whether individuals can learn to regulate their prefrontal cortex activation during emotional processing in response to feedback about their brain activation during functional magnetic resonance imaging (fMRI) scanning,” he said.

As an assistant in the TU Tough project, McDermott has led lectures in TU Tough modules and supervised small group leaders during breakout discussions. He also has managed data processing and analysis for fMRI neuroimaging scans performed before and after TU Tough treatment. Prepared by lead author Elisabeth Akeman (BS ’15) as well as Aupperle and McDermott, a recently published manuscript in the journal “Depression and Anxiety” reports findings from the first two cohorts of TU Tough. The research shows students who complete the program (compared to those who did not) experienced lower rates of self-reported stress and depression symptoms throughout their first semester of college, particularly as measured during finals week. Aupperle explained TU Tough is a strong example of LIBR research that can improve the overall mental health of Oklahomans. “By taking measures to improve resilience to stress and mental health among TU students, we are benefiting the community in general,” she said. “Supporting the health and well-being of our students is the equivalent to supporting the health and well-being of our community.”

LIBR
TU graduate student McKenna Pierson

Other ongoing treatment studies at LIBR use behavioral activation or cognitive behavioral therapy (as part of ongoing studies in Aupperle’s lab) or novel intervention approaches such as the Float Clinic and Research Center led by PI Justin Feinstein. His studies use flotation as an intervention approach to mental illness, providing patients with a way to disconnect with the world and reconnect with signals firing in their bodies. His research was featured on the CBS This Morning’s “Pay Attention” series in 2018.

TU and LIBR’s unique partnership

Paulus is pleased with the substantial data collection, analyses and treatment LIBR has been able to provide to residents within its first decade. Although Oklahoma has a long way to go in improving its overall mental health, he explained LIBR intends to serve as the starting point for large sets of basic health information that support a biotech approach to mental health treatment and diagnosis. “We want to know how far we can develop, how advanced is our research and can we potentially establish startups that can be developed into effective treatments and commercial products,” Paulus said. In one example, LIBR Chief Technology Officer and physicist Jerzy Bodurka, created a way to use a real-time MRI to train a specific part of the brain to give instant feedback on if the training is effective. Paulus explained the training has reduced levels of depression in research participants, and Bodurka now is developing a turnkey system that will allow for scalability of the intervention at any site with MRI imaging capabilities.

LIBRBehind every principal or associate investigator stands a team of student researchers eager to get involved, serving as valuable assets for LIBR’s mission. When asked if TU depends on LIBR or if LIBR relies on TU, Paulus said the partnership is unique in that it is based on both concepts; while the institute focuses on quality research, TU is a generator of knowledge. “TU’s primary mission is teaching, but the goal of our faculty is to be top-level researchers,” Paulus said. “The research provides training opportunities for students, and we couldn’t train them if we didn’t have this relationship with TU.”

Close ties to LIBR are an incentive for students, especially those at the graduate level, to choose TU for advanced experience in their field of research. Students are invited to participate in rotations through the institute and contribute to the facility’s mental health mission. Although LIBR’s primary method of research is brain imaging, Paulus said there will be opportunities for additional biology-based research in the future as researchers pursue exciting advancements into the new decade.

Three faculty named TU Outstanding Researchers

The University of Tulsa honored its inaugural group of Outstanding Researchers at spring commencement on May 4. The Outstanding Researcher Award is a lifetime distinction, received only once in an individual’s career. It is intended to honor career-spanning achievements that have been validated in the scholar’s professional field.

These are the 2018-19 recipients:

outstanding researchersRose F. Gamble, Tandy Professor of Computer Science Engineering. Gamble developed a safety and security requirements model that can be embedded and used by a self-adaptive system to intelligently determine the least risky adaptation to deploy at runtime.

outstanding researchersJamie L. Rhudy, Director of the Psychophysiology Laboratory for Affective Neuroscience and Professor of Psychology. Rhudy’s research identifies mechanisms that contribute to and/or maintain chronic pain (particularly in Native Americans) and seeks to develop non-invasive methods for assessing individuals at risk for developing chronic pain.

Outstanding ResearchersCem Sarica, F.H. “Mick” Merelli/Cimarex Energy Professor of Petroleum Engineering. Sarica’s research has been disseminated to the public at large through more than 240 publications and incorporated in various software. He has been recognized internationally with several awards by the Society of Petroleum Engineers, most notably with an SPE John Franklin Carll Award in 2015.

Candidates for the Outstanding Researcher awards were nominated by deans from the Kendall College of Arts and Sciences, College of Engineering and Natural Sciences, Collins College of Business and the Oxley College of Health Sciences. Nominees were selected for their recognition of outstanding research and scholarship achievements based on a single project or a cumulative contribution.

Other considerations included pedagogical awards, honors from scholarly societies, grants, publication citation counts or other forms of public recognition. External recognition of a faculty member’s work also factored into the selection process.

Learn more about this year’s distinguished faculty awards, including the 2018-19 Outstanding Teachers and Medicine Wheel Award recipients.